Best DNA Tests

Whether it's for health reasons or curiousity, DNA testing is quite popular. But is it right for you? We delve into the best tests and what to know about testing.

When choosing where to test one’s DNA, consider the goal of testing. Do we want health results, discoveries about our origins, or both? Then factor in the price and services offered.

It is best to test at many companies, but if you can only afford one test at a time, where should you begin? Here’s what our professional genealogist recommends:

Include your extended family in this process. Decide which family members to test first (generally the oldest frailest) with the extended family covering expenses. Over time, more family members can test. Each child inherits a different sampling of parents’ genes, so it pays to have all siblings test, as well as cousins, aunts, and uncles.

DNA testing companies do offer big discounts on holidays and flash sales, especially around Father’s Day and Mother’s Day.

A DNA kit stays fresh for at least a year if stored in a cool and dry place, so take advantage of sales. DNA kits make wonderful gifts, but be certain recipients have no objection to DNA testing before ordering. If you have family members concerned about privacy they may refuse to test and you do not want to create awkwardness.

There are other reliable companies that offer DNA testing, but these often focus narrowly--some only offer health assessments, for example. Others focus on specific populations. They lack the large databases bigger companies have built up. A large database is essential for family origin purposes.

Our results will be slightly different if we test at more than one company. This is because each company uses different algorithms in analyzing our DNA.

Evaluated is reader-supported, so this post may contain affiliate links, which means if you click on our links to make a purchase, we may make a commission at no cost to you. 

Things to Consider Before Testing:

All companies say our data is anonymized and securely stored. But experts warn that anonymized results are easily re-identified and can be linked to us. Some people fear DNA testing invades their privacy or gives government and business too much control over our lives. There is very little privacy in this world. While health insurance companies can, for the most part, no longer deny coverage due to risk or pre-existing conditions, life insurance companies do actually use DNA testing to deny coverage or cancel existing policies. It happened to two of our team members who underwent testing for the BRCA genetic mutation due to a high rate of cancer deaths in the family. These are important things to discuss with your doctor.

LAW ENFORCEMENT INCREASINGLY USES DNA TESTING

Others worry about how law enforcement uses DNA to track down criminals. If somebody wanted to analyze our DNA they can obtain a sample easily and without our knowledge.

A detective follows around a suspect for weeks and grabs a used cigarette butt from the ground to collect his DNA to solve a case. Police are typically utilizing DNA research to pursue dangerous criminals, not hunt down somebody with a speeding ticket. That relative may be your cousin, but if he is a serial killer do you really want to protect him?

On the bright side, DNA can help ensure justice is served. Cold cases from decades ago are being solved through DNA. Prisoners who were jailed for a crime they did not commit are increasingly being exonerated through DNA research.

YOUR ETHNICITY MAY SURPRISE YOU

Ethnicity results are especially troubling to DNA newbies. DNA does not lie. If our results say we have Iberian ancestors and Grandpa said we are Swedish, Grandpa is the one in error. Ethnicity is a social definition based on current political realities. The world was far different in the past. One’s paper family tree says we are Scots, but DNA may reveal that those Scots were originally Vikings.

FAMILY SECRETS MAY BE REVEALED

DNA will also reveal non-paternity events in our past, and this can be disconcerting. The stories continue to surface about family members discovering their parents aren’t their biological parents, or that they have half-siblings around the world. A non-paternity event can be sperm donation, adoption or foster parentage, adultery, incest, rape, or even being switched in the maternity ward of a careless hospital.

IN CONCLUSION:

DNA science can be hard to understand. While we await our test results it is a good idea to do some reading to prepare us to better understand those results. An excellent book to consult would be The Family Tree Guide to DNA Testing and Genetic Genealogy by Blaine T. Bettinger. It is written in easily understood language and explains the terms and concepts we need to comprehend the exciting results that will soon arrive.

DNA testing is well worth the expense, say those who have done it. It offers the potential to improve our lives and those of our descendants. It can open new worlds of understanding. Even when it brings us surprises it can enrich and deepen our sense of self.

Which Test Should I Buy?

When purchasing through Amazon, only buy a DNA test from the company who makes it, not a third party reseller. For example, if you were going to purchase an AncestryDNA test, verify that your product "Ships From Amazon," and is Sold By AncestryDNA Official. Many third-party sellers may be selling old or stolen kits that may not even be eligible to be used. 

Avoid off-brand companies. They might offer a cheap price for a kit, but their advertising does not say the buyer must then pay more to have the sample actually tested at a lab. Or the lab offers no database to upload results to and no explanation of one’s results.

When it comes to DNA testing, you really do get what you pay for!

Below is an analysis of some of the top-selling DNA tests on the market:

AncestryDNA:

For family origin, we recommend starting DNA testing with AncestryDNA’s autosomal test. AncestryDNA is a perennial favorite because of its database of over 18 million test subjects, its price, the ease of understanding one’s results, the historical context it offers, and the ability to link one’s DNA to its huge collection of family trees.

A big database of subscribers allows us to compare ourselves to more people. Autosomal tests such as AncestryDNA’s enable one to find lots of relatives on both sides of one’s family going back 5-8 generations. It does not provide the long ago results of other types of testing.

For those just starting out in family history or health it is a useful beginning. AncestryDNA finds matches and grades those matches for us, presenting them in easily interpreted and sorted tables. A match is someone with whom we share similar DNA.

AncestryDNA users report finding hundreds or thousands of matches—relatives from eighth cousins to siblings and parents. Ancestry offers a messaging service to contact these matches. Its traits feature predicts physical and other tendencies we may have. AncestryDNA’s kit is spit in the tube. It can be difficult to generate enough saliva to fill the little tube, especially for the elderly.

Which AncestryDNA test to buy? We tried Ethnicity + Traits Test.

*We recommend skipping the Ethnicity + World Explorer option (not shown below) because you pay more for it but do not get the Traits. If you are interested in an Ancestry.com membership, get that separately. You will likely be disappointed that you paid more for a membership but didn't get the full test. 

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23andMe:

If health results are desired, 23andMe is the best, and it also comes in high on the family origins scale.

23andMe offers a different focus than the genealogy-based AncestryDNA and MyHeritage tests. There is plenty of genealogy to discover at 23andMe, but the health aspects are what make it unique. Features such as predisposition, traits, wellness, family health history tree, and pharmacogenetics reports enhance our understanding of ourselves. It places us in a deeper context of history, such as how much Neanderthal DNA we carry, what our haplogroups mean and where they place us at various times in history. Some say 23andMe’s ethnicity results are the most accurate. Its analysis tools are tops, the best for a layperson’s understanding. The website is fun and easily navigable—one can spend hours learning new things. 23andMe does not accept uploads from other companies. These kits are spit in the tube.

Which 23andMe test to buy? The awesome thing about 23andMe is that you can always upgrade. We've tested with the Health & Ancestry because the health insights were important to us.

If you later decide you want to subscribe to 23andMe's membership ($29/year as of this writing), you can opt in. The new reports that come out every year are actually quite interesting.

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Comprehensive ancestry breakdown and 30+ trait reports.

  • 2000+ Geographic regions
  • DNA Relative Finder
  • 80+ personalized reports
  • Ancestry percentages (to the 0.1%)
  • Automatic Family Tree Builder
  • 2000+ geographic regions
  • Health upgrade available

If you want to get a more complete picture of your health with insights from your genetic data. Includes everything from Ancestry+Traits and:

  • 65+ health reports and features including:
  • Health Predisposition reports
  • Wellness reports
  • Carrier Status reports
  • Family Health History Tree
  • 150+ personalized reports
  • Includes Ancestry plus Traits Service
  • Includes FDA-authorized reports
  • FSA/HSA eligibility

Health + Ancestry Service plus ongoing premium reports and new features throughout the year. Includes everything in Essential and:

  • Instant access to exclusive reports and features, including:
  • Heart Health reports
  • Pharmacogenetics reports (how you process certain medications)
  • Migraine report (Powered by 23andMe research)
  • Skin Cancer (Basal and Squamous Cell Carcinomas) and Skin Cancer (Melanoma) reports (Powered by 23andMe research)
  • Plus new reports and features as more discoveries are made

MyHeritage DNA Test Kit:

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MyHeritage.com offers similar features to 23andMe. Its huge database is not as large as AncestryDNA, but much broader. MyHeritage tests widely across the world, often at no cost to users, to yield more accurate results and comparisons. It offers well over 2000 geographic regions in its ethnicity estimates, more than any other company. MyHeritage is also the #1 service for European DNA matching.

MyHeritage supports 42 ethnicities and has a vast bank of family trees to attach one’s DNA results to. Its privacy and security measures are excellent with multiple layers of encryption. MyHeritage allows users to upload DNA tests they take at other companies, for free. Consultants are available by phone to help users in understanding their results. The kit is a cheek swab, easier to do than the spit in a tube kit. MyHeritage produces fast results—3-4 weeks, where others say 6-8 weeks.

FamilyTreeDNA Family Finder DNA Kit:

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FamilyTreeDNA is for those who want to dig deeper. The kit sold on Amazon has the basic autosomal test for discovering relatives back about 5 generations.

But FamilyTreeDNA also offers Y DNA and mtDNA tests, sold on their website. These tests are not messing around. If you are serious about your family history and genetic testing, this is the way to go.

FamilyTreeDNA has its own lab and has been in the business longer than most other companies. Y DNA tests differ in price based on how many short tandem repeats (short sequences of DNA) are tested. For beginners try the two least inexpensive tests first. For experts in DNA science the most expensive will be best. The mtDNA test for women comes with a personalized video for fun and greater understanding.

For all tests, there is a customer support service and learning center on the website. Explanation of haplogroups available.

FamilyTreeDNA has the largest databases for both YDNA and mtDNA. One can join specialty genealogical research projects through FamilyTreeDNA. The health test includes a consult with health professionals and reports on traits, nutrition and diet traits, fitness traits, medication responses, disease risks, organ system diseases, cancer predisposition, carrier screening, secondary conditions. FamilyTreeDNA offers fun features such as comparing one’s DNA to that found at archaeological sites. Its kits are cheek swabs and there is free upload of DNA tests from Ancestry, 23andMe, and MyHeritage.

FamilyTreeDNA Advanced mtDNA Test

Both males and females inherit mtDNA. mtDNA testing can help you discover and verify your direct maternal ancestry by connecting you with other individuals who are descendants of a shared common matrilineal ancestor.

  • Test for both biological females and males
  • Examines all regions of mitochondrial DNA
  • Identifies your specific haplogroup and migration path
  • Get more refined DNA matches on your maternal line

FamilyTreeDNA Advanced Y-DNA Tests

These biological male-specific Y-DNA tests check for specific markers on the Y chromosome. Y-DNA is what we call the sex chromosome “Y” that is passed from a father to his sons only, women do not receive a Y chromosome. Testing the Y chromosome allows for investigation into a male's paternal family line and can help identify surname lines, living relatives whose Y chromosome is similar to yours, and ancient migration routes your paternal ancestors may have taken.

Y-DNA Y-37

  • Test is for biological males
  • Examines 37 short tandem repeats (STRs) on
    the Y chromosome
  • Compares 37 STR markers between you and your matches.
  • Predicted haplogroup (distant)

Y-DNA Y-111

  • Test is for biological males
  • Tests 111 STR markers (37 markers plus an additional 74)
  • Compares 37 STR markers between you and your matches.
  • Compares 111 STR markers between you and your matches.
  • Predicted haplogroup (distant)
  • Test is for biological males
  • Tests 111 STR markers (37 markers plus an additional 74)
  • Compares 37 STR markers between you and your matches.
  • Compares 111 STR markers between you and your matches.
  • Predicted haplogroup (distant)

Big Y-700

  • Test is for biological males
  • Tests 111 STR markers (37 markers plus an additional 74)
  • Tests 700 STR markers (111 markers plus an additional 589+ markers)
  • Compares 37 STR markers between you and your matches.
  • Compares 111 STR markers between you and your matches.
  • Includes SNP matches. With SNP matching, you can compare where you and other families fit on the family tree of mankind.
  • Confirms your haplogroup and defines your placement on the family tree of mankind.
  • Sequences 400K+ known SNPs on the Y chromosome to help you identify your family’s unique Y-chromosome mutations.
  • Confirmed haplogroup (more recent)
  • Updates over time as more evidence is available.
  • Compare matches and origins on the Big Y block tree.